I'm reading a great book r8ight now called Mind Regained by the philosopher Edward Los. He makes several great points, one of which is that reductionist materialists have no basis for asserting their own metaphysics. That is because they assert that all that "really" happens in the world can be explained by the motions and interactions of elementary particles, and that all apparent entities or causal powers at higher levels can be reduced to the lowest level. In particular, there is no such thing as "mind" as an actually effective force in the world, able to have a particular causal efficacy of its own.
Through this reduction, however, materialist have left themselves with nothing capable of recognizing that materialism is true! The "conclusions" reached by a bunch of atoms may be "successful" in the Darwinian sense, but there is no reason to think that means they are accurate. (In some or even many cases, wrong conclusions might be more helpful to survival than correct ones. Indeed, that is the very point many Darwinian reductionists make vis-a-vis morality and religion!)